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Bioinformatics with Python Cookbook

You're reading from   Bioinformatics with Python Cookbook Learn how to use modern Python bioinformatics libraries and applications to do cutting-edge research in computational biology

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Product type Paperback
Published in Nov 2018
Publisher Packt
ISBN-13 9781789344691
Length 360 pages
Edition 2nd Edition
Languages
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Author (1):
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Tiago Antao Tiago Antao
Author Profile Icon Tiago Antao
Tiago Antao
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Table of Contents (12) Chapters Close

Preface 1. Python and the Surrounding Software Ecology 2. Next-Generation Sequencing FREE CHAPTER 3. Working with Genomes 4. Population Genetics 5. Population Genetics Simulation 6. Phylogenetics 7. Using the Protein Data Bank 8. Bioinformatics Pipelines 9. Python for Big Genomics Datasets 10. Other Topics in Bioinformatics 11. Advanced NGS Processing

Introduction

In Chapter 4, Population Genetics, we used Python to analyze population genetics datasets based on real data. In this chapter, we will look at how we can use Python to simulate population genetics data. From teaching, to developing new statistical methods, to analyzing the performance of existing methods, simulated datasets have plenty of applications.

There are two kinds of simulation: one is the coalescent, going backward in time, while the second is forward-time simulation. Coalescent simulation is computationally less expensive because only the most recent generation of individuals needs to be completely rendered; previous generations only need parents of the next generation to be maintained. On the other hand, this severely limits what can be simulated because we need to complete populations to make decisions on, for example, which individuals mate. Forward-time...

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