While the open source version of NGINX is the one most people are familiar with, Nginx Inc also produces a paid, commercial variant with a number of additional features aimed at enterprise and large tier deployments. With features such as detailed live monitoring, application health checking for load balancers, and dynamic configuration reloading, there are compelling reasons to consider the Plus version.
While some may find the US $2,500 starting point a steep jump over the open source version, these additional features pit it against commercial systems at over ten times the price. Suffice to say, once you get to the point where these features become paramount to your business, the price is well worth it. You'll also be supporting the continual development of NGINX, which most organizations with the Plus version still run.