Sails

Sails is another great MVC framework for building web applications using Node.js that sometimes compares itself to Ruby on Rails. Unlike Meteor, Sails is database agnostic, so it doesn't matter which data store you choose. Sails includes some handy scaffolding tools such as an automatic RESTful API generation. Socket.io, a real-time communication framework for Node.js, is built into Sails; so including real-time functionalities in your application should be a breeze. Sails features some nice production-level automation that would typically need to be handled by a tool such as Grunt.js or Gulp (this includes the minification and bundling of CSS and JavaScript for the frontend). Sails also includes basic security and role-based authentication for your app, should you require that level of functionality. Sails could be considered a more full-fledged enterprise level framework than Express, as it has almost every feature that a popular framework such as rails has.

The Sails website...