Finding allele-specific expression with AllelicImbalance

Allele-specific expression (ASE) refers to the differential expression of alleles (different versions of a gene) in a diploid organism. It occurs when one allele is expressed more or less than the other allele, resulting in an imbalance of expression. ASE can occur in both coding and non-coding regions of the genome and can have a significant impact on the phenotype of an organism. Analyzing ASE can help with identifying genetic variations that contribute to the development of diseases such as cancer and inherited disorders.

The R Bioconductor AllelicImbalance package can be used to analyze ASE data. This package provides a set of tools for identifying, quantifying, and visualizing ASE in high-throughput sequencing data. The package can be used to quantify ASE at both the gene and transcript level and to identify differentially expressed alleles. Additionally, AllelicImbalance can help identify the genomic regions that are...