Presenting online
The simplest option to use and manage in Prezi meeting is an online presentation. This literally allows you to take a group of invited guests through a presentation that you've designed. If you have a path in your Prezi, then moving to each stage will also move the guests along with you as well. If your Prezi doesn't have paths, you can zoom around freely and your guests will also move along with you.
Audio
We obviously recommend you use some kind of audio system to speak with your guests as well. Prezi doesn't have any built-in function for using audio, so a company conference line or Skype will be sufficient enough. Make sure you mention the audio details on your invite, and also in the very first frame of your Prezi link we have in the following screenshot:
Where have they gone?
The only real danger you face when presenting online through Prezi meeting is losing people on your canvas. Because Prezi might be so new to people, they'll get excited and probably click on anything...