Using MPIO on Nano Server
Multipath I/O (MPIO) is a fault-tolerance and performance-enhancement technique that defines more than one physical path between the CPU in a computer system and its mass-storage devices through the buses, controllers, switches, and bridge devices connecting them. If one or more of these components fails, causing the path to fail, the multipath I/O logic uses an alternate path for I/O so that applications can still access their data.
In Chapter 4, Deploying Hyper-V Cluster on Nano Server, we covered how to deploy Nano Server in Hyper-Converged model using S2D. However, MPIO is not supported with S2D. In other words, there should be no MPIO on your S2D system because S2D is all single connection non-shared.
For more information about multipath I/O in Windows Server, please check the following article: https://technet.microsoft.com/library/cc725907.aspx.
In some scenarios, you need to connect Nano Server to iSCSI, Fiber Channel, and Serial Attached Storage (SAS) SAN...