Simulating selection

We will now perform an example of simulating selection with simuPOP. We will perform a simple case with dominant mutation on a single locus, along with a complex case with two loci using epistatic effects. The epistatic effect will have a required mutation on a main SNP. While this mutation is required to confer advantage, another mutation on another SNP adds up to the previous one (but does nothing on its own); this was inspired by the very real case of malarial resistance to the Sulfadoxine/Pyrimethamine drug, which always requires a mutation on the Dihydrofolate Reductase (DHFR) gene, which can be enhanced with a mutation on the Deoxyhypusine Synthase (DHPS) gene. If you are interested in finding out more, refer to the Origin and Evolution of Sulfadoxine Resistant Plasmodium falciparum article from Vinayak et al. on PLOS Pathogens at http://journals.plos...