Finding transmembrane domains with tmhmm and pureseqTM

Protein transmembrane domains are the parts of a protein that pass through the lipid bilayer of a cell membrane. These domains are typically composed of hydrophobic amino acids that allow the protein to interact with the nonpolar interior of the membrane. Transmembrane domains play an important role in many cellular processes, including cell signaling, transporting molecules, and cell adhesion. One important application of bioinformatics is identifying protein transmembrane domains from amino acid sequences. Several methods are used to identify transmembrane domains bioinformatically, including hydrophobicity analysis, in which we identify regions of a protein sequence that have a high degree of hydrophobicity and are likely to be transmembrane domains. There are also hidden Markov models that are trained to identify transmembrane domains based on a set of known transmembrane proteins. We can also use machine learning algorithms...